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KMID : 0438219750120030591
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Korea University Medical Journal
1975 Volume.12 No. 3 p.591 ~ p.602
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Effect of Beta-Adrenergic Blocking Agent, Sotalol(MJ 1999), on Cyclopropane-Epinephrine Cardiac Arrhythmia
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Abstract
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It has been shown that beta-adrenergic blocking agents dibenamine; propranolol and pronethalol significantly raise cyclopropane-epinephrine arrhythmia threshold and concluded that myocardial ectopic excitation might be attributable to the beta-adrenergic receptors.
These beta-adrenergic blocking agents, however, have pharmacologic properties other than betaadrenergic blockade, e. g., local anesthetic and/or quinidine-like effects, which might have contributed to the anti-arrhythmic properties observed. It is the author´s intention to search for the cause´ of arrhythmia using more selective beta-adrenergic blocker, Sotalol(MJ 1999).
Twenty-four mongrel dogs were anesthetized with 25% cyclopropane in semiclosed circle absorption system endotracheally and cyclopropane-epinephrine arrhythmias thresholds with or without pretreatment with Sotalol were determined. The results were compared with t-test.
Electrocardiogram and femoral arterial pressure were continuously recorded on Beckman RM 4-channel recorder. Ventilation was adjusted so that the pH and Pcoz were in the range df 7.35-7:45´ and 30-35 mm Hg, respectively.
The results were as follows:
1. The ocurrence of cardiac arrhythmias were not necessarily related to changes in blood pressure.
2. Sotalol decreased both blood pressure and heart rate, potentiated the pressor effect of epinephrine, reduced tachycardia produced by epinephrine, and increase the threshold of arrhythmia threshold by 8 to 16 times.
3 These results suggest that cyclopropane-epinephrine cardiac arrhythmias are caused- by`stimulation´of beta-adrenergic receptors. in the heart.
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